Recombinant Human IL-20,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-20;IL-20;Cytokine Zcyto10;IL20;ZCYTO10
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10，IL-19，IL-20，IL-22，IL-24 and IL-26.Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions.IL-20 exhibits approximately 28% amino acid identity with IL-10 and 76% amino acid identity with mouse IL-20.There are two heterodimeric receptor complexes for IL-20.The first is composed of IL-20 Rα and IL-20 Rβ.The second is composed of IL-22 R and IL-20 Rβ.Whereas the IL-22 R/IL-20 Rβ complex is shared with IL-24，the IL-20 Rα/IL-20 Rβ complex is shared with both IL-19 and IL-24.IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF-α and MCP-1.Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development.The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation，abnormal epidermal differentiation，and neonatal lethality.In humans，IL-20 and its receptors are up-regulated in psoriatic skin，and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis.IL-20 may also have a role in hematopoiesis.It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice.IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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