Recombinant Human ATF1/Cyclic AMP-dependent transcription factor ATF-1,BR

产品属性 Product Attributes

基本信息

别名： Cyclic AMP-dependent transcription factor ATF-1;cAMP-dependent transcription factor ATF-1;Activating transcription factor 1;
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain，belongs to the bZIP family.It influences cellular physiologic processes by regulating the expression of downstream target genes，which are related to growth，survival，and other cellular activities.ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3')，a sequence present in many viral and cellular promoters.It also binds to the Tax-responsive element (TRE) of HTLV-I.ATF1 mediates PKA-induced stimulation of CRE-reporter genes，represses the expression of FTH1 and other antioxidant detoxification genes，triggers cell proliferation and transformation.ATF1 is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases，cAMP-dependent protein kinase A，calmodulin-dependent protein kinase I/II，mitogen- and stress-activated protein kinase and CDK3.Its phosphorylation enhances its transactivation and transcriptional activities，and enhances cell transformation.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。