Recombinant Human Killer cell lectin-like receptor subfamily B member 1/KLRB1/CD161,BR

产品属性 Product Attributes

基本信息

别名： Killer cell lectin-like receptor subfamily B member 1;KLRB1;CLEC5B;NKRP1A;CD161;Natural killer cell surface protein P1A;NKR-P1A;HNKR-P1a;C-type lectin domain family 5 member B;KLRB1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Killer cell lectin-like receptor subfamily B，member 1(KLRB1) is a single-pass type II membrane protein which contains 1 C-type lectin domain.KLRB1 plays an inhibitory role on natural killer (NK) cells cytotoxicity.Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide.Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3.It acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1，3)Gal epitope as well as to the N-acetyllactosamine epitope.Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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