Recombinant Mouse LAG-3/CD223/Lymphocyte activation gene 3 Protein,BR

产品属性 Product Attributes

基本信息

别名： Lymphocyte activation gene 3 protein;CD223;Lag3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Lymphocyte-activation gene 3 (LAG3)，also known as CD223，is a type I transmembrane protein with four extracellular Ig-like domains，designated D1 to D4 and belongs to the immunoglobulin superfamily.The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene.LAG3 is expressed on activated T cells，natural killer cells，B cells and plasmacytoid dendritic cells.LAG3 binds with high affinity to MHC class II molecules，and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction.LAG3 negatively regulates cellular proliferation，activation，and homeostasis of T cells，and plays an important role in Treg suppressive function.LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders.The soluble form，sLAG-3，is being developed as a cancer drug.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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