Recombinant Human CREG/CREG1/Protein CREG1,BR

产品属性 Product Attributes

基本信息

别名： CREG1;cellular repressor of E1A-stimulated genes;cellular repressor of E1A-stimulated genes 1CREG;protein CREG1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Cellular repressor of E1A genes (CREG) is an evolutionarily conserved lysosomal protein，and an important new factor in regulating tissue homeostasis that has been shown to antagonize injury of tissues or cells.CREG contains three mannose 6-phosphate (M6P) markers，and depends on interactions with M6P receptors for efficient delivery to lysosomes，which is implicated in the regulation of lysosomal functions.This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro.CREG plays an important role in the control of cell growth and differentiation.It has been shown that CREG antagonizes transcriptional and cellular transformation by the adenoviral E1A oncoprotein，induces differentiation while attenuating cellular proliferation，regulates the levels of the signaling kinases ERK1/2，and mediates glucocorticoid-induced proliferation of ileal epithelial cells.CREG is widely expressed in adult tissues，such as the brain，heart，lungs，liver，intestines and kidneys in mice，but is not markedly expressed in pluripotent embryonic stem cells.
来源： Human Cells

其它标识

溶剂: Dissolve the lyophilized protein in distilled water.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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