Recombinant Human IL-10RA/Interleukin-10 Receptor Subunit Alpha/IL-10 Rα,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-10 receptor subunit alpha;IL-10 receptor subunit alpha;IL-10R subunit alpha;IL-10RA;CDw210a;Interleukin-10 receptor subunit 1;IL-10R subunit 1;IL-10R1;CD210;IL10RA
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin-10 Receptor alpha (IL-10Rα) is a transmembrane glycoprotein member of the class II cytokine receptor family.Mature human IL-10 Rα consists of a 214 amino acid (aa) extracellular domain (ECD)，a 21 aa transmembrane segment，and a 322 aa cytoplasmic domain.Within the ECD，human IL-10 Rα shares 59% aa sequence identity with mouse and rat IL-10Rα.IL-10 Rα is required for mediating the effects of IL-10，a critical molecule in the control of microbial infections，allergic and autoimmune inflammation，and cancer.IL-10Rα is the ligand specific subunit of the IL-10 receptor complex.Noncovalent dimers of IL-10 bind to IL-10 Rα，resulting in the recruitment of IL-10 Rβ.Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2，4，or 9，enabling strengthened immune responses during infection.Polymorphisms of human IL-10 Rα may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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