Recombinant Human CXCL2/GRO beta/MIP-2/CINC-3,BR

产品属性 Product Attributes

基本信息

别名： C-X-C Motif Chemokine 2;Growth-Regulated Protein Beta;Gro-Beta;Macrophage Inflammatory Protein 2-Alpha;MIP2-Alpha;CXCL2;GRO2;GROB;MIP2A;SCYB2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Chemokine Ligand 2 (CXCL2) is a small secreted cytokine which belongs to the CXC chemokine family.It is secreted by monocytes and macrophages and chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.It has been known to regulate immune functions mainly by chemo-attracting neutrophils.It is produced by activated monocytes and neutrophils and expressed at sites of inflammation.It is a hematoregulatory chemokine，which suppresses hematopoietic progenitor cell proliferation.It can be induced by receptor activator of NF-kappaB ligand，the osteoclast (OC) differentiation factor，through JNK and NF-kappaB signaling pathways in OC precursor cells.CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK.Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs.During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs.CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
来源： E.coli

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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