Recombin human DDIT4 protein,BR

产品属性 Product Attributes

基本信息

基因名: DDIT4
别名: Dig2，FLJ20500，REDD-1，REDD1，RTP801
全名: DNA-damage-inducible transcript 4
英文名称: Recombinant human DDIT4 protein
中文名称: DNA损伤诱导型转录本4
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： Q9NX09
Gene ID： 54541
交叉反应： Human Mouse Rat (Bovine Gorilla)
分子量： 25kDa
区间范围： 1-232aa
背景说明： Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1).Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB.Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage.Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity.Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity).Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity).Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity.Required for normal neuron migration during embryonic brain development.Plays a role in neuronal cell death
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

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