Recombin human SGTA protein,BR

产品属性 Product Attributes

基本信息

基因名: SGTA
别名: Alpha-SGT;UBP;Vpu-binding protein;SGT;SGT1;
全名: small glutamine-rich tetratricopeptide repeat (TPR)-containing，alpha
英文名称: Recombinant human SGTA protein
中文名称: 富含谷氨酰胺的四肽重复序列蛋白α
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Liquid: Supplied as a 0.2 μm filtered solution of 20mM Tris, 20mM NaCl, 1mM EDTA, 10% Gly, pH8.0.
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at < -70°C for 6 months.Please minimize freeze-thaw cycles.
运输条件: The product is shipped on dry ice.Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： O43765
Gene ID： 6449
交叉反应： Human Mouse Rat (Bovine)
分子量： 34kDa
区间范围： 1-314aa
背景说明： Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

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注意事项 Considerations

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