U0126,98%

Butanedinitrile,2,3-bis[amino[(2-aminophenyl)thio]methylene]-

(订货以英文名为准)

产品编号：B22430 CAS：109511-58-2 分子式：C₁₈H₁₆N₆S₂ MDL：MFCD11046040 品牌：Acmec

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中文名称：

U0126

英文名称：

Butanedinitrile,2,3-bis[amino[(2-aminophenyl)thio]methylene]-

CAS No.：

109511-58-2

分子式：

C₁₈H₁₆N₆S₂

分子量：

380.49

熔点：

approximate 154°C(dec.)

沸点：

565.1±50.0°C(Predicted)

溶解性：

DMSO:Soluble;Water:Insoluble

水溶性：

Insoluble

保存条件：

-20°C

InChIKey：

DVEXZJFMOKTQEZ-JYFOCSDGSA-N

InChI：

InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+

Pubchem ID：

3006531

U-0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor.

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

危化品级别：

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