Anti-PSEN1 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PSEN1 Polyclonal Antibody
中文名称： 早老素蛋白-1抗体
规格： 100ul ; 50ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human ; Rat
应用： IHC ; WB ; IF
稀释比例： WB 1:500-2000. IHC 1:50-200. IF 1:50-200

抗体信息

靶标： PSEN1
别名： Presenilin-1 NTF subunit, AD 3, AD3, Ad3h, Alzheimer Disease 3, EC 3.4.23., FAD, Homo Sapiens Clone CC44 Senilin 1, Presenilin 1 Alzheimer disease 3, Presenilin 1, Presenilin1, Protein S182, PS 1, PS-1, PS1, PSEN 1, PSEN1, PSN 1, PSN1, PSN1_HUMAN, PSNL 1, PSNL1, S182, S182 Protein, Senilin 1, Senilin1
背景说明： Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Swiss Prot： P49768
Gene ID： 5663
亚细胞定位： Cytoplasm Cell membrane
免疫原： Recombinant protein of human PSEN1
Public Immunogen Range： 290-380aa
理论分子量： 53kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.02% sodium azide，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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