Anti-RAG2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-RAG2 Polyclonal Antibody
中文名称： V(D)J重组激活蛋白抗体
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Mouse ; Human
应用： WB
稀释比例： WB 1:500-2000

抗体信息

靶标： RAG2
别名： RAG 2, RAG-2, RAG2, RAG2_HUMAN, Recombination activating gene 2, V(D)J recombination activating protein 2, V(D)J recombination-activating protein 2
背景说明： This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
Swiss Prot： P55895
Gene ID： 5897
亚细胞定位： Nucleus
免疫原： Recombinant protein of human RAG2
Public Immunogen Range： 351-527aa
理论分子量： 59kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 0.03% Proclin300，50% glycerol，pH7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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