Anti-PPP4R2 Polyclonal Antibody,BR

产品属性 Product Attributes

基本信息

英文名称： Anti-PPP4R2 Polyclonal Antibody
规格： 50ul ; 100ul
宿主： Rabbit
克隆类型： Polyclonal Antibody
亚型： IgG
交叉反应：： Monkey ; Human
应用： WB
稀释比例： WB 1:1000-3000.

抗体信息

靶标： PPP4R2
别名： PPP4R2,SBBI57,Serine/threonine-protein phosphatase 4 regulatory subunit 2,SBBI57
背景说明： Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Swiss Prot： Q9NY27
Gene ID： 151987
亚细胞定位： Nucleus Cytoplasm
免疫原： A synthetic peptide of Human PPP4R2
Public Immunogen Range： 367-417/417aa
理论分子量： 40/46kDa

其它标识

纯化方法： Affinity purification
储存液： PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3.
储存条件： Store at -20℃. Avoid freeze/thaw cycles.

产品介绍 Product Introduction

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注意事项 Considerations

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