Recombinant Human TRAIL R2/TNFRSF10B/CD262/DR5/KILLER/Fas-like protein,BR

产品属性 Product Attributes

基本信息

别名： Tumor Necrosis Factor Receptor Superfamily Member 10B;Death Receptor 5;TNF-Related Apoptosis-Inducing Ligand Receptor 2;TRAIL Receptor 2;TRAIL-R2;CD262;TNFRSF10B;DR5;KILLER;TRAILR2;TRICK2;ZTNFR9
中文名称: Recombinant Human TRAIL R2/TNFRSF10B/CD262/DR5/KILLER/Fas-like protein
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： TNFRSF10B is a member of the TNF-receptor superfamily，and contains an intracellular death domain.This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L)，and transduces apoptosis signal.The adapter molecule FADD recruits caspase-8 to the activated receptor and is required for the apoptosis mediated by TNFRSF10B.TNFRSF10B is expressed in a number of cell types，and to particularly high levels in lymphocytes and spleen.This single-pass transmembrane protein contains two cysteine-rich repeat units in its extracellular region，followed by a transmembrane segment and a cytoplasmic tail containing a typical “death domain”.TNFRSF10B expression is regulated by the tumor suppressor p53.It is also indicated that the activation of NF-kappa-B can be promoted by TNFRSF10B.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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