Recombinant Human CD33/Siglec-3,BR

产品属性 Product Attributes

基本信息

别名： Myeloid Cell Surface Antigen CD33;Sialic Acid-Binding Ig-Like Lectin 3;Siglec-3;gp67;CD33;SIGLEC3
中文名称: Recombinant Human CD33/Siglec-3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 2mM EDTA, pH 7.2.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： CD33 is a type I Lectin belonging to the Ig superfamily.CD33 contains an N terminal Ig like V type domain，which mediates sialic acid binding，followed by one Ig like C2 type domain，a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs).Eleven human Siglecs have been characterized.Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions.They are collectively referred to as CD33 related Siglecs.CD33 related Siglecs have differential expression pattern within the hematopoietic system.They are involved in the regulation of cellular activation within the immune system.Siglec 3 expression is restricted to cells of myelomonocytic lineage.Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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