Recombinant Mouse Chordin-like protein 2/CHL2/CHRDL2,BR

产品属性 Product Attributes

基本信息

别名： Chordin-like protein 2;BNF-1;CHRDL2;chordin-like 2;chordin-like protein 2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Mouse Chordin-Like 2，also known as CHL2，is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis.The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide.The mature chain of CHL2 protein contains two potential N-linked glycosylation sites，one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs).CHL2 gene is weakly expressed in the liver and kidney，partly expressed in the connective tissues of reproductive organs such as ligaments of the ovary and oviduct in females，and of testis，epididymis and certain male accessory sex glands in males.Recombinant mCHL2 protein interacted directly with five BMPs and one GDF thereby inhibiting，in vitro，several BMP/GDF-dependent processes including，osteogenic differentiation of C2C12 mesenchymal progenitor cells by several BMPs，ATDC5 embryonal carcinoma cells by GDF5 and BMP4-dependent lymphohematopoietic (CD34+CD31hi and CD34+CD31lo) progenitor cell development from ES cells.CHL2 may inhibits BMPs activity by blocking their interaction with their receptors，and has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells，by preventing or reducing the rate of matrix accumulation.Also，it may play a role during myoblast and osteoblast differentiation，and maturation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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