Recombin human ELAVL4 protein,BR

产品属性 Product Attributes

基本信息

基因名: ELAVL4
别名: HUD；PNEM
全名: ELAV (embryonic lethal，abnormal vision，Drosophila)-like 4 (Hu antigen D)
英文名称: Recombinant human ELAVL4 protein
中文名称: ELAV样蛋白4
规格: 10ug ; 50ug ; 100ug ; 1mg
外观:(性状) Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. (Or liquid with 5% glycerol.)
纯度: ≥85% by SDS-PAGE.
储存条件: Reconstituted protein solution can be stored at 4-7°C for 1-2 weeks, stored at < -20°C for 1 year.
运输条件: The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below.
浓度: 1mg/ml by SDS-PAGE.

产品信息

Swiss Prot： P26378
Gene ID： 1996
交叉反应： Human Mouse Rat (Zebrafish)
分子量： 40kDa
区间范围： 1-367aa
背景说明： RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs .Plays a role in the regulation of mRNA stability, alternative splicing and translation.Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA .Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function.By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay.Also binds to the polyadenylated tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding.Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms.Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells.Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA.Binds and stabilizes MSI1 mRNA in neural stem cells.Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression .Protects CDKN1A mRNA from decay by binding to its 3'-UTR.May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization.Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function.Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain.By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth.Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC.By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration.Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing.Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex.May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation.Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished.Also plays a role in the regulation of alternative splicing.May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA.
应用： Immunology research
来源： E.coli

其它标识

纯化方法： NI-NTA affinity purification
溶剂： Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.)
内毒素： Not measured
生物活性： N0
标签信息： With a 6×His tag at the N/C-terminus.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。