D-半乳糖(用于动物造模),≥98%

产品属性 Product Attributes

基本信息

CAS：59-23-4

中文名称：D-半乳糖(用于动物造模)

英文名称：D-Galactose（For Animal Modeling ）

别名：D-半乳糖; D-(+-Galactose)

分子式：C₆H₁₂O₆

分子量：180.16

规格：1g ; 5g ; 10g ; 25g ; 50g ; 100g

溶解性：Soluble in Water ≥10mg/mL

纯度：≥98%

级别：Animal Modeling

外观(性状)：White to off-white Solid

储存条件：Powder:RT,2 years;Insolvent(母液):-20℃,6 months;-80℃,1 year

其它标识

EC：200-416-4

MDL：MFCD00151230

SMILES：C([C@@H]1[C@@H]([C@@H]([C@H](C(O1)O)O)O)O)O

InChIKey：WQZGKKKJIJFFOK-SVZMEOIVSA-N

InChI：InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H，1H2/t2-，3+，4+，5-，6?/m1/s1

PubChem CID：6036

Beilstein Number：1724619

储备液配制表 *

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。

储备液的保存方式和期限：-80°C, 1 year; -20°C, 6 months。-80°C储存时，请在1年内使用，-20°C储存时，请在6个月内使用。

产品介绍 Product Introduction

In Vivo

Mice（male Kunming mice；500.00 mg kg−1 day−1 D-gal；hypodermic injection；8 weeks）

The mice had free access to food and water during the week-long of adaptive feeding. After one week of acclimatization, the mice were randomly divided into 5 groups (Blank,Model, WO, PSO, CSO). The first week of the experiment, apart from the blank group (treated with saline), all the mice in the 4 other groups received 500.00 mg kg−1 day−1 D-gal by hypodermic injection for 8 weeks. The first two weeks, all groups were supplied by maintenance fodder.

文献来源：Kang T, Zheng J, Jiang C, Jin L, Li C, Chen B, Shen Y. Amelioration of walnut, peony seed and camellia seed oils against D-galactose-induced cognitive impairment in mice by regulating gut microbiota. Food Funct. 2024 Jul 1;15(13):7063-7080. doi: 10.1039/d4fo01409j. PMID: 38867661.

Mice（male Kunming mice；300 mg/kg ；D-gal；intraperitoneally injected；42 days）

The experimental animals used in this experiment were Kunming mice (n = 36, male, 8-week-old, 25 ± 4 g), provided by the Laboratory Animal Center of Dali University. The mice were kept in a relatively constant environment (temperature 25 ± 1 ◦C, humidity 60 % ± 5 %) with alternating light and dark cycles for 12 h. After adaptation, the patients were randomly divided into control group (saline, n = 12), D-gal group (300 mg/kg D-gal, n = 12) and GAS group (300 mg/kg D-gal+78 mg/kg gastrodin injection, n = 12). D-gal group and GAS group were intraperitoneally injected with D-gal once a day for 42 days to establish the aging mouse model, and mice in control group were intraperitoneally injected with the same amount of saline every day.

文献来源：Li J, Yuan R, Zheng S, Wang Y, Miao J. Exploring the impact of Gastrodin on brain aging in mice: Unraveling mechanisms through network pharmacology. Biochem Biophys Res Commun. 2025 Jun 1;764:151814. doi: 10.1016/j.bbrc.2025.151814. Epub 2025 Apr 15. PMID: 40250323.

Mice（ICR；6 weeks old；1 % D-galactose；subcutaneous injection；28 days）

A total of 60 mice (ICR, SPF grade, male, 6 weeks old, weight 28.0 ±1.5 g) were randomly and equally divided into control, D-galactose(Solarbio, batch No. 1013I056), 0.2 g/kg metformin, 3.6 g/kg ginseng water decoction, 1.8 g/kg GWD , and 0.9 g/kg GWD (half equivalent dose) groups. The dosage was calculated by multiplying 12.3 according to the equivalent dose coefficient of human and mouse body surface area in “Pharmacological Experimental Methodology.” The quality control of GWD was the same as previous study (Wu et al., 2020). According to the dosing volume of 10 mL/kg,mice were injected with 1 % D-galactose aqueous solution subcutaneously on the back of the neck to establish an aging model for 28 days.

文献来源：Guo LL, Yan RY, Du Z, Li HB, Li GL, Wu SH. Ginseng promotes the function of intestinal stem cells through the Wnt/β-catenin signaling pathway in D-galactose-induced aging mice. Exp Gerontol. 2024 Jan;185:112351. doi: 10.1016/j.exger.2023.112351. Epub 2023 Dec 23. PMID: 38135257.

Mice（male Kunming mice；ip；52 days）

The AD model mice were replicated by injection of D-gal intraperitoneally and fed with high-fat diet for 56 consecutive days. The AD model mice were orally administered with high dosed BYHWD at 58.58 g/kg/d calculated with herbs (BHD-H
group), middle-dosed BYHWD at 29.29 g/kg/d (BHD-M group), low-dosed BYHWD at 14.64 g/kg/d (BHD-L group) from day 1 to day 52. Donepezil at the dose of 2.06mg/kg/d(donepezil group) was used as positive control. In steadily, mice in control group were injected intraperitoneally with saline and orally administered saline for 52 consecutive days.

文献来源：Jiang J, Duo K, Zhu S, Wang Y, Xue H, Piao C, Ren Y, Lei X, Zhang Y, Liu J, Yang L, Zhang N. Investigation of the mechanism of Buyang Huanwu decoction in improving learning and memory impairment in Alzheimer's disease mice based on lipidomics. J Nat Med. 2025 May;79(3):568-590. doi: 10.1007/s11418-025-01890-x. Epub 2025 Apr 7. PMID: 40195204; PMCID: PMC12058831.

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。