雷帕霉素,98%
Rapamycin
(订货以英文名为准)猜你喜欢
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雷帕霉素用途及描述:科研试剂,广泛应用于分子生物学,药理学等科研方面。
雷帕霉素(西罗莫司)是新型大环内酯的抗排斥药物,是目前世界上最新的强效免疫抑制剂。本品抑制由抗原和细胞因子(白介素IL-2、IL-4和IL-15)激发的T淋巴细胞的活化和增殖,它亦抑制抗体的产生。在细胞中,西罗莫司与免疫嗜素,即FK结合蛋白-12(FKBP-12)结合,生成FKBP-12免疫抑制复合物。此复合物与哺乳动物的西罗莫司BA分子(mTOR,一种关键的调节激酶)结合并抑制其活性,从而抑制细胞周期中G1期向S期的发展。
储存条件:-20℃,避光防潮密闭干燥。
Product Description
Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were recently identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12target). Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Enhances apoptosis.SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
雷帕霉素用途是什么?
提问时间:2021/7/8 11:41:36
雷帕霉素是做什么用的?哪里可以用到雷帕霉素?
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回复内容:
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admin2021-09-06 10:20:26
雷帕霉素用作免疫抑制剂;A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa鈥橬ui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN
), also known as rapamycin, is an immunosu
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雷帕霉素的水溶性怎么样?
提问时间:2021/6/30 12:58:44
雷帕霉素在水中的溶解性怎么样?
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回复内容:
1
admin2021-06-30 12:58:44
雷帕霉素的水溶性为:Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water.
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