Recombinant Human UBE2V1/Uev1a (Mms2),BR

产品属性 Product Attributes

基本信息

别名： Ubiquitin-Conjugating Enzyme E2 Variant 1;UEV-1;CROC-1;TRAF6-Regulated IKK Activator 1 Beta Uev1A;UBE2V1;CROC1;UBE2V;UEV1;P/OKcl.19
中文名称: Recombinant Human UBE2V1/Uev1a (Mms2)
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) is a member of the Ubiquitin-conjugating (E2) enzyme family.The E2 catalytic core domain of UBE2V1 lacks an active site cysteine residue，rendering it catalytically inactive on its own.However，in the cytoplasm UBE2V1 is able to form a catalytically active complex with UBE2N/Ubc13，which mediates the synthesis Lys63-linked Ubiquitin chains and is required for NF-kappa B activation.UBE2V1 is required for UBE2N (Ubc13)/UBE2V1 Complex-dependent Lys63-linked Ubiquitin chain formation.More specifically，UBE2V1 orients the Ubiquitin molecule to favor linkage at Lys63 via a non-covalent interaction with the Ubiquitin molecule.The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys63.This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome.UBE2V1 plays a role in the activation of NF-kappa-B mediated by IL1B，TNF，TRAF6，and TRAF2.It mediates transcriptional activation of target genes.UBE2V1 also controls the progress through the cell cycle and differentiation，the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
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3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。