Recombinant Human HGF R/c-MET/Hepatocyte Growth Factor Receptor (Glu25-Thr932),BR

产品属性 Product Attributes

基本信息

别名： Hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met;MET
中文名称: Recombinant Human HGF R/c-MET/Hepatocyte Growth Factor Receptor (Glu25-Thr932)
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development.HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage.Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain.Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain，consist of secreted extracellular domains，or are deficient in proteolytic separation of the α and β chains.The sema domain，which is formed by both α and β chains of HGF R，mediates both ligand binding and receptor dimerization.HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation.Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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