Recombinant Human EGFR/HER1/ERBB1,BR

产品属性 Product Attributes

基本信息

别名： Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB;ERBB1;HER1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： EGFR is a transmembrane glycoprotein that is a member of the protein kinase superfamily.This protein is a receptor for members of the epidermal growth factor family.EGFR is a cell surface protein that binds to epidermal growth factor.Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation.Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK，PI3 kinase-AKT，PLCgamma-PKC and STATs modules.May also activate the NF-kappa-B signaling cascade.Also directly phosphorylates other proteins like RGS16，activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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