Recombinant Human IL-1RI/Interleukin-1 Receptor Type 1/IL-1R-1,BR

产品属性 Product Attributes

基本信息

别名： Interleukin-1 receptor type 1;IL-1R-1;IL-1RT-1;IL-1RT1;CD121 antigen-like family member A;Interleukin-1 receptor alpha;IL-1R-alpha;p80;CD121a
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Interleukin 1 receptor，type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family.IL-1R1 is an 80 kDa transmembrane protein that is expressed predominantly by T cells，fibroblasts，and endothelial cells.This gene along with IL1R2，IL1RL2，and IL1RL1 form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses.It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B，MAPK and other pathways.The signaling involves the recruitment of adapter molecules such as TOLLIP，MYD88，and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.It also binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.An IL1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL1α or IL1β but not IL1ra，was identified.Recombinant IL1 soluble receptor Type I is a potent antagonist of IL1 action.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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