Recombinant Human VEGFC/Flt4 ligand/Flt4-L/vascular endothelial growth factor C,BR

产品属性 Product Attributes

基本信息

别名： Vascular Endothelial Growth Factor C;VEGF-C;Flt4 Ligand;Flt4-L;Vascular Endothelial Growth Factor-Related Protein;VRP;VEGFC
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Vascular Endothelial Growth Factor (VEGF)-C is a member of the VEGF family，a group of polypeptide growth factors which play key roles in the physiology and pathology of many aspects of the cardiovascular system，including vasculogenesis，hematopoiesis，angiogenesis and vascular permeability.While VEGFC is homologous to other members of the VEGF/PDGF family，it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs.Upon biosynthesis，VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion.VEGF signalling in endothelial cells occurs through three tyrosine kinase receptors (VEGFRs) expressed by endothelial cells and hematopoietic precursors，and VEGF-C is a ligand for two receptors，VEGFR-3 (Flt4)，and VEGFR-2.It is indicated that VEGFC undergoes a complex proteolytic maturation generating a variety of processed secreted forms with increased activity toward VEGFR-3，but only the fully processed form could activate VEGFR-2.VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis，and also in the maintenance of differentiated lymphatic endothelium in adults.Knockout of the VEGF-C gene is embryonic lethal late in development，and although cells differentiate into the lymphatic lineage，they fail to sprout and form lymphatic vessels.Inactivation of a single VEGF-C allele results in the development of cutaneous lymphatic hypoplasia and lymphedema.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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