Recombinant Human Kininogen,BR

产品属性 Product Attributes

基本信息

别名： Kininogen-1;lpha-2-Thiol Proteinase Inhibitor;Fitzgerald Factor;High Molecular Weight Kininogen;HMWK;Williams-Fitzgerald-Flaujeac Factor;KNG1;BDK;KNG
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM Hac-NaAC, 150mM NaCl, pH 4.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Kininogen-1 is a secreted protein which contains three cystatin domains.There are two alternatively spliced forms，designated as the high molecular weight (HMW) and low MW (LMW) forms.Kininogen-1 plays a critical role in blood coagulation and inflammatory response.Kininogens are inhibitors of thiol proteases.Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII，also inhibits the thrombin- and plasmin-induced aggregation of thrombocytes.The active peptide bradykinin that is released from Kininogen-1 shows a variety of physiological effects: influence in smooth muscle contraction，induction of hypotension，natriuresis and diuresis，decrease in blood glucose level.It is a mediator of inflammation and causes increase in vascular permeability，stimulation of nociceptors release of other mediators of inflammation.It has a cardioprotective effect.LMW-kininogen inhibits the aggregation of thrombocytes and doesn’t involved in blood clotting.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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