Recombinant Human Endothelin-converting Enzyme 1/ECE-1,BR

产品属性 Product Attributes

基本信息

别名： Endothelin-converting enzyme 1;ECE-1
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Endothelin-Converting Enzyme-1 (ECE-1) is a single-pass type I I transmembrane (TM) protein with a short cytoplasmic tail and a large ectodomain.ECE-1 is a zinc protease of the neprilysin (NEP) family，which also includes ECE-2，PEX，XCE，DINE，and Kell，and several NEP-like proteins.It is widely expressed and has several alternatively spliced forms that differ in their TM domain or cytoplasmic tail.All isoforms of ECE-1 are expressed in umbilical vein endothelial cells，polynuclear neutrophils，fibroblasts，atrium cardiomyocytes and ventricles.Endothelin-converting enzyme-1 is involved in the proteolytic processing of Endothelin-1 (EDN1)，Endothelin-2 (EDN2)，and Endothelin-3 (EDN3) to biologically active peptides.Defects in ECE1 are a cause of Hirschsprung disease，cardiac defects and autonomic dysfunction (HSCRCDAD).It is a form of Hirschsprung disease with skip-lesions defects，craniofacial abnormalities and other dysmorphic features，and autonomic dysfunction.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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