Recombinant Human ISG15/UCRP,BR

产品属性 Product Attributes

基本信息

别名： Ubiquitin-Like Protein ISG15;Interferon-Induced 15 kDa Protein;Interferon-Induced 17 kDa Protein;IP17;Ubiquitin Cross-Reactive Protein;hUCRP;ISG15;G1P2;UCRP
中文名称: Recombinant Human ISG15/UCRP
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： Ubiquitin-Like Protein ISG15 (ISG15) is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha and -beta.Several functions have been ascribed to the encoded protein，including chemotactic activity towards neutrophils，direction of ligated target proteins to intermediate filaments，cell-to-cell signaling，and antiviral activity during viral infections.While conjugates of this protein have been found to be noncovalently attached to intermediate filaments，this protein is sometimes secreted.ISG15 becomes conjugated to a diverse set of proteins after IFN-alpha/beta stimulation or microbial challenge.The functions or biochemical consequences ISG15 conjugation to proteins are not yet known，but it appears that this modification does not target proteins for proteasomal degradation.ISG15 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors.Upon interferon treatment，ISG15 can be detected in both free and conjugated forms，and is secreted from monocytes and lymphocytes where it can function as a cytokine.In the cell，ISG15 co-localizes with intermediate filaments and ISGylation may modulate the JAK-STAT pathway or certain aspects of neurological disease.
来源： E.coli

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

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