Recombinant Human HTRA2/Serine protease HTRA2,BR

产品属性 Product Attributes

基本信息

别名： Serine protease HTRA2;mitochondrial;High temperature requirement protein A2;HtrA2;Omi stress-regulated endoprotease;Serine protease 25;Serine proteinase OMI;HTRA2;OMI;PRSS25
中文名称: Recombinant Human HTRA2/Serine protease HTRA2
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH7.5.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： High temperature requirement protein A2(HTRA2) is a single-pass membrane protein.It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family.HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2.It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins，IAPs)，leading to an increase in caspase activity，or by a BIRC inhibition-independent，caspase-independent and serine protease activity-dependent mechanism.The protein cleaves THAP5 and promotes its degradation during apoptosis.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。