Recombinant Human HVEM/TNFRSF14/CD270,BR

产品属性 Product Attributes

基本信息

别名： Tumor Necrosis Factor Receptor Superfamily Member 14;Herpes Virus Entry Mediator A;Herpesvirus Entry Mediator A;HveA;Tumor Necrosis Factor Receptor-Like 2;TR2;CD270;TNFRSF14;HVEA;HVEM
中文名称: Recombinant Human HVEM/TNFRSF14/CD270
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, PH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily，and it can both promote and inhibit T cell activity.HVEM is highly expressed on native CD4+ T cells，CD8+ T memory cells，regulatory T cells，dendritic cells，monocytes，and neutrophils.It functions as a receptor for BTLA，CD160，LIGHT/TNFSF14，and Lymphotoxin-alpha.Ligation of HVEM by LIGHT triggers T cell，monocyte，and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection.In contrast，HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation.HVEM enhances the development of CD8+ T cell memory and Treg function.It is additionally expressed on intestinal epithelial cells，where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense.The herpesvirus envelope glycoprotein gD，which binds HVEM to initiate membrane fusion，can antagonize both BTLA and LIGHT binding.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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