Recombinant Human Flt-3/Flk-2/CD135/Tyrosine-protein kinase receptor FLT3,BR

产品属性 Product Attributes

基本信息

别名： Receptor-Type Tyrosine-Protein Kinase FLT3;FL Cytokine Receptor;Fetal Liver Kinase-2;FLK-2;Fms-Like Tyrosine Kinase 3;FLT-3;Stem Cell Tyrosine Kinase 1;STK-1;CD135;FLT3;FLK2;STK1
中文名称: Recombinant Human Flt-3/Flk-2/CD135/Tyrosine-protein kinase receptor FLT3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Supplied as a 0.2 μm filtered solution of PBS,PH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

产品信息

背景说明： The Flt-3 (fms-like tyrosine kinase) receptor，also named Flk-2and Stk-1is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT，the receptor for SCF and FMS，the receptor for M-CSF.The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain.Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide，a 515 aa extracellular domain with 10 potential N-linked glycosylation sites，a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain.Flt-3 expression has been detected in various tissues，including placenta，gonads，and tissues of nervous and hematopoietic origin.Among hematopoietic cells，the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations.The ligand for Flt-3 (FL) has been identified to be a transmembrane protein with structural homology to M-CSF and SCF.Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist.
来源： Human Cells

其它标识

内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

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