Recombinant Human SLAMF5/SLAM Family Member 5/CD84,BR

产品属性 Product Attributes

基本信息

别名： SLAM family member 5;Cell surface antigen MAX.3;Hly9-beta;Leukocyte differentiation antigen CD84;Signaling lymphocytic activation molecule 5;CD84;SLAMF5
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： SLAM family member 5 (SLAMF5/CD84) is a type I transmembrane protein in the SLAM subgroup of the CD2 family.SLAM family proteins regulate multiple aspects of immune system function.Mature human CD84 consists of a 204 amino acid (aa) extracellular domain (ECD) with two Iglike domains，a 21 aa transmembrane segment，and a 99 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs (ITSMs).CD84 exhibits homophilic binding which is mediated by the N-terminal Ig-like domain.Ligation induces tyrosine phosphorylation in the cytoplasmic ITSMs which then recruit the signaling adaptor molecules SAP (SLAM-associated protein) and EAT-2(EWS/Fli1-activated transcript 2).CD84 signaling inhibits Fc epsilon RI-induced mast cell activation but enhances platelet activation.LPS-induced macrophage activation，T cell proliferation and IFN-γproduction，and the interactions between T cells and B cells that are required for germinal center formation.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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