Recombinant Human Serpin B9,BR

产品属性 Product Attributes

基本信息

别名： Cytoplasmic antiproteinase 3;Peptidase inhibitor 9;CAP3;PI-9;Serpin B9
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Serpin B9，also known as Cytoplasmic antiproteinase 3(CAP-3)，is a cytoplasm protein which belongs to the large superfamily of serine proteinase inhibitors (serpins)，which bind to and inactivate serine proteinases.Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway.It is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines.These interactions are involved in many cellular processes，including coagulation，fibrinolysis，complement fixation，matrix remodeling，and apoptosis.Serpin-B9 expression in immune-privileged cells，APCs，and CTLs protects these cells against the actions of granzyme B，and when expressed in tumor cells or virally infected hepatocytes，confers resistance to killing by CTL and NK cells.Expression of increasing levels of Serpin-B9 in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin / granzyme pathway and then through the Fas / FasL pathway.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

产品介绍 Product Introduction

暂无数据

注意事项 Considerations

1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。
2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。
3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。