Recombinant Human PIP4K2A/Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha,BR

产品属性 Product Attributes

基本信息

别名： 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha;Diphosphoinositide kinase 2-alpha;PIP5KIII;Phosphatidylinositol 5-phosphate 4-kinase type II alpha;PtdIns(4)P-5-kinase B isoform;PtdIns(4)P-5-kinase C isoform;PtdIns(5)P-4-kinase isoform 2-alpha
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

产品信息

背景说明： Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family.It contains 1 PIPK domain and is expressed ubiquitously，with high levels in the brain.It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring，to form phosphatidylinositol 4，5-bisphosphate (PtdIns(4，5)P2).It may exert its function by regulating the levels of PtdIns5P，which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2.It may regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation，negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.It also involved in thrombopoiesis，and the terminal maturation of megakaryocytes and regulation of their size.
来源： Human Cells

其它标识

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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